Joint & Ortho

BioActive Coll Joint

Regenerative Intra-Articular Therapy
for osteoarthritis and joint degeneration

BioActive Coll Joint is an advanced intra-articular formulation based on bioactive Type I collagen peptides, engineered to support joint regeneration, reduce inflammation, and relieve pain.
Designed specifically for early to moderate osteoarthritis and joint deterioration, this injectable solution acts locally and systemically to restore functional joint health through biological stimulation.

How It Works

Dual Action: local repair, systemic support

Enzymatic Activation in the Synovial Space

Once injected into the joint cavity, BioActive Coll Joint is rapidly degraded by matrix metalloproteinases (MMPs) present in the synovial fluid. This natural enzymatic process breaks the collagen into bioactive peptides capable of modulating the local tissue environment.

Local Tissue Regeneration

These peptides engage directly with immune cells, chondrocytes, and fibroblasts in the joint, promoting anti-inflammatory signaling and triggering cartilage repair. This leads to enhanced extracellular matrix remodeling, improved joint lubrication, and reduced structural degradation.

Lymphatic Absorption and Systemic Circulation

High-molecular-weight peptides are absorbed via the lymphatic system and released into the bloodstream, where they support broader tissue recovery. Glycine, proline, and hydroxyproline—key amino acids released during metabolism—play crucial roles in protein synthesis, wound healing, and antioxidant defense.

Biomechanical Reinforcement

By improving matrix quality and cell-matrix interactions, BioActive Coll Joint contributes to better biomechanical stability of the joint, supporting smoother motion and reduced mechanical stress.

Proven Clinical Benefits

Validated by Real-World Outcomes

Pain Relief

In clinical settings, patients receiving BioActive Coll Joint experienced a 30–40% reduction in VAS pain scores after four injections—substantially outperforming placebo.

Improved Function

Significant and sustained improvements in WOMAC and SF-36 scores highlight the therapy’s impact on mobility, flexibility, and quality of life.

Medical Devices

Inflammation Control

Collagen peptides actively modulate cytokine pathways, helping mitigate chronic inflammation that drives joint degeneration.

Cartilage Protection and Repair

By stimulating chondrocyte activity and ECM synthesis, BioActive Coll Joint helps protect and restore damaged cartilage.

Safety and Tolerability

Clinical studies report a favorable safety profile with no serious adverse events. The formulation is well-tolerated across multiple treatment cycles.

Indications

BioActive Coll Joint is indicated for:

  • Early-stage knee osteoarthritis (OA)
  • Post-traumatic joint degeneration
  • Joint pain and stiffness in aging populations
  • Adjunct therapy in regenerative orthopedics

Why Choose
BioActive Coll Joint?

Bioengineered for Joint Microenvironments

Formulated to interact with the biological and mechanical complexity of the synovial joint.

Supports Long-Term
Joint Health

Not just a symptomatic treatment—BioActive Coll Joint addresses the underlying degeneration through regeneration.

Easy Integration
Into Orthopedic Protocols

Designed for use by orthopedic specialists, sports medicine clinicians, and rehabilitation practitioners.

Ready to Join the Future

Contact our team to access clinical documentation,
product training, or to become a certified provider.

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MEDICAL DEVICES

CDMO SERVICES

R&D INNOVATION

  • Next Generation Capabilities
  • Research Project
  • Clinical Studies

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